Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.

Multiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) characterized by immune-mediated inflammation, demyelination and subsequent axonal damage. Gene expression profiling showed that Nurr1, an orphan nuclear receptor, is down-regulated in peripheral blood monon...

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Main Authors: Francesca Montarolo, Chiara Raffaele, Simona Perga, Serena Martire, Annamaria Finardi, Roberto Furlan, Samuel Hintermann, Antonio Bertolotto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4181297?pdf=render
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spelling doaj-6868c289d5f34c39ac82be45e00773ad2020-11-25T01:46:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10879110.1371/journal.pone.0108791Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.Francesca MontaroloChiara RaffaeleSimona PergaSerena MartireAnnamaria FinardiRoberto FurlanSamuel HintermannAntonio BertolottoMultiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) characterized by immune-mediated inflammation, demyelination and subsequent axonal damage. Gene expression profiling showed that Nurr1, an orphan nuclear receptor, is down-regulated in peripheral blood mononuclear cells of MS patients. Nurr1 exerts an anti-inflammatory role repressing the activity of the pro-inflammatory transcription factor NF-kB. Here, we report that the preventive treatment with isoxazolo-pyridinone 7e, an activator of Nurr1 signaling pathway, reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). The compound is able to attenuate inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process.http://europepmc.org/articles/PMC4181297?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Francesca Montarolo
Chiara Raffaele
Simona Perga
Serena Martire
Annamaria Finardi
Roberto Furlan
Samuel Hintermann
Antonio Bertolotto
spellingShingle Francesca Montarolo
Chiara Raffaele
Simona Perga
Serena Martire
Annamaria Finardi
Roberto Furlan
Samuel Hintermann
Antonio Bertolotto
Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
PLoS ONE
author_facet Francesca Montarolo
Chiara Raffaele
Simona Perga
Serena Martire
Annamaria Finardi
Roberto Furlan
Samuel Hintermann
Antonio Bertolotto
author_sort Francesca Montarolo
title Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
title_short Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
title_full Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
title_fullStr Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
title_full_unstemmed Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
title_sort effects of isoxazolo-pyridinone 7e, a potent activator of the nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description Multiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) characterized by immune-mediated inflammation, demyelination and subsequent axonal damage. Gene expression profiling showed that Nurr1, an orphan nuclear receptor, is down-regulated in peripheral blood mononuclear cells of MS patients. Nurr1 exerts an anti-inflammatory role repressing the activity of the pro-inflammatory transcription factor NF-kB. Here, we report that the preventive treatment with isoxazolo-pyridinone 7e, an activator of Nurr1 signaling pathway, reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). The compound is able to attenuate inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process.
url http://europepmc.org/articles/PMC4181297?pdf=render
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