Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells

Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells

Abstract Background Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies. However, whether PKM2 regulates the radiosensitivity of human cervical cancer (CC) remains unknown. Methods The expression of PKM2 i...

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Bibliographic Details
Main Authors: Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He, Xinping Cao
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cancer Cell International
Subjects:
Radiosensitivity
Apoptosis
Cell cycle
Double strand break repair
Online Access:http://link.springer.com/article/10.1186/s12935-019-0845-7

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