Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease[S]

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent complication of obesity, yet cellular mechanisms that lead to its development are not well defined. Previously, we have documented hepatic steatosis in mice carrying a mutation in the Sec61a1 gene. Here we examined the mechanism behind N...

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Bibliographic Details
Main Authors: Matthew C. Wheeler, Nicholas Gekakis
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520353335