Autologous hematopoietic stem cell transplantation for diabetic foot: A meta-analysis

• Main Authors: Guo-Dong Qi, Qiong Jiang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2021-04-01
• Series: Journal of Hainan Medical University
• Subjects: diabetic foot; autologous hematopoietic stem cells; cell transplantation; meta-analysis
• Online Access: http://www.hnykdxxb.com/PDF/202107/08.pdf

Objective: To systematically evaluate the efficacy and safety of autologous hematopoietic stem cell（AHSCs） transplantation for diabetic foot（DF）. Methods: A systematic search of literatures in PubMed, Embase, the Cochrane Library, CNKI, WanFang and VIP from inception to March 2020 was conducted. Clinical randomized controlled trials of AHSCs transplantation for DF were screened according to inclusion and exclusion criteria, and meta-analysis was performed using RevMan 5.3 software. Results: A total of 13 articles were included, including 582 patients within 292 received conventional treatment in the control group and 290 additionally received AHSCs in the transplantation group. Meta-analysis results showed that compared with the control group, the transplantation group improved ulcer healing rate [RR=2.38,95%CI(1.91,2.98),P <0.00001],ankle brachial index[MD=0.14, 95%CI(0.11,0.16), P <0.00001]and skin temperature of injured limb[MD=1.39,95%CI(0.93,1.86),P <0.00001]. And lowered mutation rate[RR=0.10,95%CI(0.04,0.26),P <0.00001], pain scores[MD=- 1.37,95%CI(-1.62,-1.12),P <0.00001]and indirect claudication scores[MD=-0.89,95%CI(- 1.04,-0.75),P <0.00001]. The above differences were all statistically significant (P < 0.05). Conclusion: Existing evidence shows that AHSCs transplantation for DF has certain clinical effects and safety. However, more high-quality research are needed to further demonstrate the above results.