Vancomycin: the need to suit serum concentrations in hemodialysis patients

Vancomycin: the need to suit serum concentrations in hemodialysis patients

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The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several ha...

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Main Authors: Lívia Luize Marengo, Fernando de Sá Del Fiol, Sara de Jesus Oliveira, Celso Nakagawa, Eduardo Leite Croco, Silvio Barberato-Filho, Marcela Pellegrini Peçanha, Douglas Felix da Silva, Maria Inês de Toledo
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Brazilian Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867010700416
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spelling doaj-684e8fea65084fbeb98eb960b18365b32020-11-25T01:29:41ZengElsevierBrazilian Journal of Infectious Diseases1413-86702010-03-01142203208Vancomycin: the need to suit serum concentrations in hemodialysis patientsLívia Luize Marengo0Fernando de Sá Del Fiol1Sara de Jesus Oliveira2Celso Nakagawa3Eduardo Leite Croco4Silvio Barberato-Filho5Marcela Pellegrini Peçanha6Douglas Felix da Silva7Maria Inês de Toledo8Pharmacy School of Universidade de Sorocaba PIBIC-CNPqResearcher of the Reference Center on Information About Antibiotics (CRIA) of Universidade de SorocabaResearcher of the Reference Center on Information About Antibiotics (CRIA) of Universidade de SorocabaConjunto Hospitalar de SorocabaConjunto Hospitalar de SorocabaResearcher of the Reference Center on Information About Antibiotics (CRIA) of Universidade de SorocabaFaculdade de Ciências Médicas e da Saúde - PUC São PauloResearcher of the Reference Center on Information About Antibiotics (CRIA) of Universidade de SorocabaResearcher of the Reference Center on Information About Antibiotics (CRIA) of Universidade de Sorocaba; Faculdade de Tecnologia de Sorocaba; Correspondence to: Rua Silvério E. Oliveira, 160 – Jd. Saira Sorocaba – São Paulo – Brazil CEP: 18085-645 Phone: 55 15 3238 5266.The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86% of trough vancomycin serum concentrations were below the recommended value, indicating exposure to subtherapeutic doses and a higher risk for selecting resistant microorganisms. Keywords: vancomycin, chronic renal failure, hemodialysishttp://www.sciencedirect.com/science/article/pii/S1413867010700416
collection DOAJ
language English
format Article
sources DOAJ
author Lívia Luize Marengo
Fernando de Sá Del Fiol
Sara de Jesus Oliveira
Celso Nakagawa
Eduardo Leite Croco
Silvio Barberato-Filho
Marcela Pellegrini Peçanha
Douglas Felix da Silva
Maria Inês de Toledo
spellingShingle Lívia Luize Marengo
Fernando de Sá Del Fiol
Sara de Jesus Oliveira
Celso Nakagawa
Eduardo Leite Croco
Silvio Barberato-Filho
Marcela Pellegrini Peçanha
Douglas Felix da Silva
Maria Inês de Toledo
Vancomycin: the need to suit serum concentrations in hemodialysis patients
Brazilian Journal of Infectious Diseases
author_facet Lívia Luize Marengo
Fernando de Sá Del Fiol
Sara de Jesus Oliveira
Celso Nakagawa
Eduardo Leite Croco
Silvio Barberato-Filho
Marcela Pellegrini Peçanha
Douglas Felix da Silva
Maria Inês de Toledo
author_sort Lívia Luize Marengo
title Vancomycin: the need to suit serum concentrations in hemodialysis patients
title_short Vancomycin: the need to suit serum concentrations in hemodialysis patients
title_full Vancomycin: the need to suit serum concentrations in hemodialysis patients
title_fullStr Vancomycin: the need to suit serum concentrations in hemodialysis patients
title_full_unstemmed Vancomycin: the need to suit serum concentrations in hemodialysis patients
title_sort vancomycin: the need to suit serum concentrations in hemodialysis patients
publisher Elsevier
series Brazilian Journal of Infectious Diseases
issn 1413-8670
publishDate 2010-03-01
description The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86% of trough vancomycin serum concentrations were below the recommended value, indicating exposure to subtherapeutic doses and a higher risk for selecting resistant microorganisms. Keywords: vancomycin, chronic renal failure, hemodialysis
url http://www.sciencedirect.com/science/article/pii/S1413867010700416
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