Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety

Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety

Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly i...

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Main Authors: Niamh O’Halloran, Donald Courtney, Michael J Kerin, Aoife J Lowery
Format: Article
Language:English
Published: SAGE Publishing 2017-08-01
Series:Breast Cancer: Basic and Clinical Research
Online Access:https://doi.org/10.1177/1178223417726777
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spelling doaj-684c7bde119d45dab28326b6f250a9a52020-11-25T01:25:46ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342017-08-011110.1177/1178223417726777Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological SafetyNiamh O’Halloran0Donald Courtney1Michael J Kerin2Aoife J Lowery3Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland, Galway, Galway, IrelandDiscipline of Surgery, Lambe Institute for Translational Research, National University of Ireland, Galway, Galway, IrelandDiscipline of Surgery, Lambe Institute for Translational Research, National University of Ireland, Galway, Galway, IrelandGraduate Entry Medical School, University of Limerick, Limerick, IrelandAdipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.https://doi.org/10.1177/1178223417726777
collection DOAJ
language English
format Article
sources DOAJ
author Niamh O’Halloran
Donald Courtney
Michael J Kerin
Aoife J Lowery
spellingShingle Niamh O’Halloran
Donald Courtney
Michael J Kerin
Aoife J Lowery
Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety
Breast Cancer: Basic and Clinical Research
author_facet Niamh O’Halloran
Donald Courtney
Michael J Kerin
Aoife J Lowery
author_sort Niamh O’Halloran
title Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety
title_short Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety
title_full Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety
title_fullStr Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety
title_full_unstemmed Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety
title_sort adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
publisher SAGE Publishing
series Breast Cancer: Basic and Clinical Research
issn 1178-2234
publishDate 2017-08-01
description Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.
url https://doi.org/10.1177/1178223417726777
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