Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1β

Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1β

No therapy currently exists to repair demyelinated lesions in multiple sclerosis. However, the use of IgM antibodies may provide a valuable therapeutic avenue for evoking such repair. Unfortunately, the mechanism of immunoglobulin action in CNS repair is currently unknown but may depend upon complex...

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Bibliographic Details
Main Authors: Charles L. Howe, Sonia Mayoral, Moses Rodriguez
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
Interleukin-1β
Fcμ
IgM
Remyelination
Demyelination
CNS Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001501

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