Diagnosis of diabetes mellitus and pre-diabetes with fasting plasma glucose, oral glucose tolerance test and A1C level: A1C based screening may be a better diagnostic tool for diabetes mellitus

• Main Authors: Mehmet Ozgur Niflioglu, Mithat Bahceci, Sakine Leyla Aslan, James Shawcross, Ece Harman, Aliye Pelin Tutuncuoglu.
• Format: Article
• Language: English
• Published: Society of TURAZ AKADEMI 2012-12-01
• Series: Medicine Science
• Subjects: Diabetes Mellitus; Fasting Plasma Glucose; Oral Glucose Tolerance Test; HbA1c
• Online Access: http://www.ejmanager.com/fulltextpdf.php?mno=24910
• ISSN: 2147-0634

OBJECTIVE: The International Diabetes Federation estimates that 285 million people around the world have diabetes. The American Diabetes Association (ADA) has proposed hemoglobin A1C ≥ 6.5% (HbA1c) for the diagnosis of diabetes, and 5.7-6.4% as a risk factor for progression to diabetes. This new criterions accuracy is controversial and has not yet been adopted internationally. We aimed to clarify the power of A1C in diagnosis of diabetes and pre-diabetes. RESEARCH DESIGN AND METHODS: In this retrospective study a total of 1814 patients (622 male, 1192 female) who had concurrent FPG, OGTT and A1C results and diabetes mellitus suspicion were included by using the hospital ProBel system. Diabetic subjects and patients who had been using drugs that may cause diabetes were excluded. RESULTS: According to ADA criteria; 760 of 1814 individuals had diabetes mellitus (41.8 %). With each of these tests (HbA1c, 2-h OGTT and FPG), diabetes was detected in 529 (69.6%), 488 (64.2%) and 328 (43.2%) subjects respectively. Differences between, FPG, 2-h OGTT; FPG and HbA1c; 2-h OGTT and HbA1c were statistically significant (p [Med-Science 2012; 1(4.000): 341-50]