Synthetic Genistein Glycosides Inhibiting EGFR Phosphorylation Enhance the Effect of Radiation in HCT 116 Colon Cancer Cells

Synthetic Genistein Glycosides Inhibiting EGFR Phosphorylation Enhance the Effect of Radiation in HCT 116 Colon Cancer Cells

The need to find new EGFR inhibitors for use in combination with radiotherapy in the treatment of solid tumors has drawn our attention to compounds derived from genistein, a natural isoflavonoid. The antiproliferative potential of synthetic genistein derivatives used alone or in combination with ion...

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Bibliographic Details
Main Authors: Aleksandra Gruca, Zdzisław Krawczyk, Wiesław Szeja, Grzegorz Grynkiewicz, Aleksandra Rusin
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
genistein glycoconjugates
epidermal growth factor receptor inhibition
radiotherapy
radiosensitization
Online Access:http://www.mdpi.com/1420-3049/19/11/18558

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http://www.mdpi.com/1420-3049/19/11/18558

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