The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial

A single centre, single-blinded, prospective, randomized, controlled clinical study was conducted to evaluate the effectiveness of twice weekly fluorescent light energy therapy (Phovia™) as adjunct to systemic antibiotics in the management of deep pyoderma in dogs. Dogs with clinical lesions consist...

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Main Authors: Andrea Marchegiani, Alessandro Fruganti, Andrea Spaterna, Matteo Cerquetella, Adolfo M. Tambella, Susan Paterson
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Veterinary Medicine International
Online Access:http://dx.doi.org/10.1155/2021/6643416
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spelling doaj-683546e941d9438dbf96dbbc7db58a6e2021-02-15T12:53:13ZengHindawi LimitedVeterinary Medicine International2090-81132042-00482021-01-01202110.1155/2021/66434166643416The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical TrialAndrea Marchegiani0Alessandro Fruganti1Andrea Spaterna2Matteo Cerquetella3Adolfo M. Tambella4Susan Paterson5School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, ItalyVirtual Vet Derms Ltd. Lakeview, 3 High Birkrigg Park, Stainton, Kendal LA80DY, UKA single centre, single-blinded, prospective, randomized, controlled clinical study was conducted to evaluate the effectiveness of twice weekly fluorescent light energy therapy (Phovia™) as adjunct to systemic antibiotics in the management of deep pyoderma in dogs. Dogs with clinical lesions consistent with deep pyoderma, positive bacterial culture, and showing neutrophil engulfing bacteria at cytology were included in the study. Assessments were undertaken weekly for 8 weeks and every 2 weeks thereafter until 12 weeks after enrolment. At each visit, lesions were scored and cytology was conducted to determine a neutrophil engulfing bacteria score. All dogs (Groups A and B) were treated with systemic antibiotic twice daily, and Group B received additionally Phovia twice weekly. Median treatment duration was 11.7 weeks for Group A and 5.7 weeks for Group B. After 8 weeks of treatment, the percentage of dogs that achieved clinical resolution was 35.0% and 88.0% for Groups A and B, respectively. Lesion scores showed highly statistically significant difference in favour of Group B from week 3 to 8, and neutrophil engulfing bacteria scores showed statistical difference from week 2 onwards in favour of Group B. These results indicate that Phovia, when used as an adjunct to systemic antibiotics, can accelerate time to clinical resolution in cases of canine deep pyoderma.http://dx.doi.org/10.1155/2021/6643416
collection DOAJ
language English
format Article
sources DOAJ
author Andrea Marchegiani
Alessandro Fruganti
Andrea Spaterna
Matteo Cerquetella
Adolfo M. Tambella
Susan Paterson
spellingShingle Andrea Marchegiani
Alessandro Fruganti
Andrea Spaterna
Matteo Cerquetella
Adolfo M. Tambella
Susan Paterson
The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial
Veterinary Medicine International
author_facet Andrea Marchegiani
Alessandro Fruganti
Andrea Spaterna
Matteo Cerquetella
Adolfo M. Tambella
Susan Paterson
author_sort Andrea Marchegiani
title The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial
title_short The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial
title_full The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial
title_fullStr The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial
title_full_unstemmed The Effectiveness of Fluorescent Light Energy as Adjunct Therapy in Canine Deep Pyoderma: A Randomized Clinical Trial
title_sort effectiveness of fluorescent light energy as adjunct therapy in canine deep pyoderma: a randomized clinical trial
publisher Hindawi Limited
series Veterinary Medicine International
issn 2090-8113
2042-0048
publishDate 2021-01-01
description A single centre, single-blinded, prospective, randomized, controlled clinical study was conducted to evaluate the effectiveness of twice weekly fluorescent light energy therapy (Phovia™) as adjunct to systemic antibiotics in the management of deep pyoderma in dogs. Dogs with clinical lesions consistent with deep pyoderma, positive bacterial culture, and showing neutrophil engulfing bacteria at cytology were included in the study. Assessments were undertaken weekly for 8 weeks and every 2 weeks thereafter until 12 weeks after enrolment. At each visit, lesions were scored and cytology was conducted to determine a neutrophil engulfing bacteria score. All dogs (Groups A and B) were treated with systemic antibiotic twice daily, and Group B received additionally Phovia twice weekly. Median treatment duration was 11.7 weeks for Group A and 5.7 weeks for Group B. After 8 weeks of treatment, the percentage of dogs that achieved clinical resolution was 35.0% and 88.0% for Groups A and B, respectively. Lesion scores showed highly statistically significant difference in favour of Group B from week 3 to 8, and neutrophil engulfing bacteria scores showed statistical difference from week 2 onwards in favour of Group B. These results indicate that Phovia, when used as an adjunct to systemic antibiotics, can accelerate time to clinical resolution in cases of canine deep pyoderma.
url http://dx.doi.org/10.1155/2021/6643416
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