Use of polymer combinations in the preparation of solid dispersions of a thermally unstable drug by hot-melt extrusion

Use of polymer combinations in the preparation of solid dispersions of a thermally unstable drug by hot-melt extrusion

The objective of the study was to prepare solid dispersions containing a thermally unstable drug by hot-melt extrusion (HME). Carbamazepine (CBZ) was selected as model drug and combinations of Kollidon VA64 (VA64), Soluplus (SOL) and Eudragit EPO (EPO) were utilized as carriers. Preformulation was c...

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Bibliographic Details
Main Authors: Jia Liu, Feng Cao, Can Zhang, Qineng Ping
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Carbamazepine
Hot-melt extrusion
Thermal unstable drug
Solid dispersion
Polymer combination
Stability
Dissolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383513000646

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