FILAMENTARY KERATITIS ETIOLOGY ANALYSIS, ITS COMBINATION WITH SYSTEMIC DISEASES AND ETIOPATHOGENIC TREATMENT REGIMENS

• Main Authors: D. Y. Maychuk, I. A. Pronkin, Y. V. Kolubelova
• Format: Article
• Language: Russian
• Published: Publishing house "Ophthalmology" 2015-10-01
• Series: Офтальмохирургия
• Subjects: filamentary keratitis; 0.05% cyclosporine a
• Online Access: https://www.ophthalmosurgery.ru/jour/article/view/53

Purpose. To analyze concomitant pathology contributing to filamentary keratitis and its incidence and to evaluate an effectiveness of different treatment regimens.Material and methods. The examination included 30 patients (60 eyes) with filamentary keratitis. All patients were divided into 3 groups depending on treatment regimen: group 1 – Vitabact, Hylozar-comod, Balarpan, Corneregel 4 t/d; group 2 – the same reparative treatment and dexamethasone; group 3 – the same reparative treatment and 0.05% cyclosporine A. Among investigative methods there were following diagnostic methods: patients’ questionnaire, biomicroscopy, 5-region corneal fluorescein staining scale, Shirmer test – 1, TBUTtest. Follow-up period was 6 months.Results. Concomitant diseases were revealed in 100% of patients (89.5% – endocrine pathology or rheumatoid diseases). Shirmer test results were variable and no appropriateness and dependency on treatment regimen were found. All other tests detected data increased dramatically at the 2-3 weeks of follow-up in the groups 1 and 2, but dropped down also very quickly after 1 month. In the group 3 improvement indices were slowly, but stayed stable for the whole follow-up period.Conclusion. 1. Endocrine pathology or rheumatoid diseases or their combination appear in 89.5% of patients. 2. Dexamethasone as a component of combined therapy contributed to rapid filaments’ resorption and to stop symptoms of dry eye syndrome. 3. Restasis promotes a stable remission.