The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg

Alongside the chemical and physical research of nucleic acids in the 1940s-50s, the mechanisms of their biosynthesis were investigated. Thus, in 1959, Severo Ochoa and Arthur Kornberg were awarded the Nobel Prize in Physiology or Medicine for the discovery of the mechanisms of biological synthesis o...

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Main Authors:	O. P. Matyshevska, V. M. Danilova, S. V. Komisarenko
Format:	Article
Language:	English
Published:	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2021-02-01
Series:	Ukrainian Biochemical Journal
Subjects:	severo ochoa arthur kornberg rna dna enzymes polynucleotide phosphorylase dna polymerase i dna ligase replication
Online Access:	http://ukrbiochemjournal.org/wp-content/uploads/2021/02/Matyshevska_1_21.pdf

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spelling	doaj-681e6c74853040678152929d8f81bba72021-03-04T12:44:18ZengNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.Ukrainian Biochemical Journal2409-49432413-50032021-02-0193112913810.15407/ubj93.01.129The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. KornbergO. P. Matyshevska0V. M. Danilova1S. V. Komisarenko2https://orcid.org/0000-0002-3244-3194Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkrainePalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkrainePalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineAlongside the chemical and physical research of nucleic acids in the 1940s-50s, the mechanisms of their biosynthesis were investigated. Thus, in 1959, Severo Ochoa and Arthur Kornberg were awarded the Nobel Prize in Physiology or Medicine for the discovery of the mechanisms of biological synthesis of RNA and DNA. The experiments performed by Ochoa and Kornberg are considered today the cornerstone of genetic engineering, as they first demonstrated the possibility of synthesizing RNA and DNA outside the living cell, and also as the enzymes they discovered were among the first tools of this technology.http://ukrbiochemjournal.org/wp-content/uploads/2021/02/Matyshevska_1_21.pdfsevero ochoaarthur kornbergrnadnaenzymespolynucleotide phosphorylasedna polymerase idna ligasereplication
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	O. P. Matyshevska V. M. Danilova S. V. Komisarenko
spellingShingle	O. P. Matyshevska V. M. Danilova S. V. Komisarenko The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg Ukrainian Biochemical Journal severo ochoa arthur kornberg rna dna enzymes polynucleotide phosphorylase dna polymerase i dna ligase replication
author_facet	O. P. Matyshevska V. M. Danilova S. V. Komisarenko
author_sort	O. P. Matyshevska
title	The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg
title_short	The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg
title_full	The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg
title_fullStr	The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg
title_full_unstemmed	The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg
title_sort	discovery of the mechanisms of biological synthesis of nucleic acids: 1959 nobel laureates s. ochoa and a. kornberg
publisher	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
series	Ukrainian Biochemical Journal
issn	2409-4943 2413-5003
publishDate	2021-02-01
description	Alongside the chemical and physical research of nucleic acids in the 1940s-50s, the mechanisms of their biosynthesis were investigated. Thus, in 1959, Severo Ochoa and Arthur Kornberg were awarded the Nobel Prize in Physiology or Medicine for the discovery of the mechanisms of biological synthesis of RNA and DNA. The experiments performed by Ochoa and Kornberg are considered today the cornerstone of genetic engineering, as they first demonstrated the possibility of synthesizing RNA and DNA outside the living cell, and also as the enzymes they discovered were among the first tools of this technology.
topic	severo ochoa arthur kornberg rna dna enzymes polynucleotide phosphorylase dna polymerase i dna ligase replication
url	http://ukrbiochemjournal.org/wp-content/uploads/2021/02/Matyshevska_1_21.pdf
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The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg

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