MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer

MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer

Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and lacks definite treatment targets. Tumor immune microenvironment (TIME) heterogeneity has a profound impact on the immunotherapy response. Tumors with non-inflamed TIME derive limited benefit from immu...

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Bibliographic Details
Main Authors:	Yi Xiao, Xi Jin, Xin Hu, Jin-Li Wei, Si-Yu Wu, Xiao-En Xu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2021-07-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/9/7/e002528.full

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