Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation

Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation

Primary human hepatocytes are commonly used to evaluate liver drug metabolism and toxicity. Pluripotent stem cell derived hepatocytes (SCDHs) have the potential to overcome access and function-related limitations associated with primary hepatocytes. SCDHs may also provide an improved system for eval...

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Bibliographic Details
Main Authors:	Jenna L. Voellinger, Edward J. Kelly
Format:	Article
Language:	English
Published:	International Association of Physical Chemists (IAPC) 2016-06-01
Series:	ADMET and DMPK
Online Access:	http://pub.iapchem.org/ojs/index.php/admet/article/view/280

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