Microbial biofilm correlates with an increased antibiotic tolerance and poor therapeutic outcome in infective endocarditis

Microbial biofilm correlates with an increased antibiotic tolerance and poor therapeutic outcome in infective endocarditis

Abstract Background Infective endocarditis (IE) is associated with high rates of mortality. Prolonged treatments with high-dose intravenous antibiotics often fail to eradicate the infection, frequently leading to high-risk surgical intervention. By providing a mechanism of antibiotic tolerance, whic...

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Main Authors: Enea Gino Di Domenico, Sara Giordana Rimoldi, Ilaria Cavallo, Giovanna D’Agosto, Elisabetta Trento, Giovanni Cagnoni, Alessandro Palazzin, Cristina Pagani, Francesca Romeri, Elena De Vecchi, Monica Schiavini, Daniela Secchi, Carlo Antona, Giuliano Rizzardini, Rita Barbara Dichirico, Luigi Toma, Daniela Kovacs, Giorgia Cardinali, Maria Teresa Gallo, Maria Rita Gismondo, Fabrizio Ensoli
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Microbiology
Online Access:http://link.springer.com/article/10.1186/s12866-019-1596-2

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http://link.springer.com/article/10.1186/s12866-019-1596-2

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