Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.

Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.

The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium sal...

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Main Authors: Timo A Immel, Ulrich Groth, Thomas Huhn, Peter Öhlschläger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3061874?pdf=render
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spelling doaj-68115dfe576a4c719ce8759b5a3c7d532020-11-25T01:46:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0163e1786910.1371/journal.pone.0017869Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.Timo A ImmelUlrich GrothThomas HuhnPeter ÖhlschlägerThe anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.http://europepmc.org/articles/PMC3061874?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Timo A Immel
Ulrich Groth
Thomas Huhn
Peter Öhlschläger
spellingShingle Timo A Immel
Ulrich Groth
Thomas Huhn
Peter Öhlschläger
Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
PLoS ONE
author_facet Timo A Immel
Ulrich Groth
Thomas Huhn
Peter Öhlschläger
author_sort Timo A Immel
title Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
title_short Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
title_full Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
title_fullStr Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
title_full_unstemmed Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
title_sort titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2011-01-01
description The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
url http://europepmc.org/articles/PMC3061874?pdf=render
work_keys_str_mv AT timoaimmel titaniumsalancomplexesdisplaysstrongantitumorpropertiesinvitroandinvivoinmice
AT ulrichgroth titaniumsalancomplexesdisplaysstrongantitumorpropertiesinvitroandinvivoinmice
AT thomashuhn titaniumsalancomplexesdisplaysstrongantitumorpropertiesinvitroandinvivoinmice
AT peterohlschlager titaniumsalancomplexesdisplaysstrongantitumorpropertiesinvitroandinvivoinmice
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