The chromatin remodeling protein BRG1 modulates BRCA1 response to UV irradiation by regulating ATR/ATM activation

The chromatin remodeling protein BRG1 modulates BRCA1 response to UV irradiation by regulating ATR/ATM activation

The SWI/SNF chromatin remodeling complex plays a role in the repair of UV-induced DNA damage. It was proposed that chromatin remodeling activities are utilized to increase the accessibility of NER machinery and checkpoint factors to the damaged DNA. It was shown recently that BRCA1 contributes to UV...

Full description

Bibliographic Details
Main Authors: Ling eZhang, Hua eChen, Ming eGong, Feng eGong
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Oncology
Subjects:
BRCA1
nucleotide excision repair
UV irradiation
BRG1
SWI/SNF
ATR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00007/full

Similar Items

Similar Items