β-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-κB Signal Pathway: In Silico and In Vivo

β-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-κB Signal Pathway: In Silico and In Vivo

Gouty arthritis serves as an acute reaction initiated by the deposition of monosodium urate (MSU) crystals around the joints. In this study, the anti-inflammatory effects of phytochemical β-caryophyllene on MSU crystal-induced acute gouty arthritis in vivo and in silico were explored. Through bioinf...

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Bibliographic Details
Main Authors: Wan-Yang Li, Fan Yang, Ji-Hua Chen, Guo-Feng Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
β-caryophyllene
gout
monosodium urate
nucleotide-binding oligomerization domain-like receptor protein 3
nuclear factor kappa-B
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.651305/full

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