Selective changes of GABA-A channel subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

Selective changes of GABA-A channel subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

Alcohol dependence is a common chronic relapsing disorder. The development of alcohol dependence has been associated with changes in brain GABA-A channel-mediated neurotransmission and plasticity. We have examined mRNA expression of the GABA-A channel subunit genes in three brain regions in individu...

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Bibliographic Details
Main Authors: Zhe eJin, Igor eBazov, Olga eKononenko, Esa R Korpi, Georgy eBakalkin, Bryndis eBirnir
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hippocampus
GABA
alcohol
Cortex
GABAA receptors
tonic inhibition
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00030/full

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