Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer

Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer

Inflammasomes comprise a family of cytosolic multi-protein complexes that modulate the activation of cysteine-aspartate-specific protease 1 (caspase-1) and promote the maturation and secretion of interleukin (IL)-1β and IL-18, leading to an inflammatory response. Different types of inflammasomes are...

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Bibliographic Details
Main Authors: Jiexia Wen, Bin Xuan, Yang Liu, Liwei Wang, Li He, Xiangcai Meng, Tao Zhou, Yimin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
NLRC4
inflammasome
autoimmune disease
cancer
PANoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702527/full

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