MgAl monolayer hydrotalcite increases the hypoglycemic effect of berberine by enhancing its oral bioavailability

MgAl monolayer hydrotalcite increases the hypoglycemic effect of berberine by enhancing its oral bioavailability

Berberine (BBR) is a potential novel agent to treat diabetes, but its oral bioavailability is restricted by the poor solubility, which greatly limits its clinical application. Here, a new drug delivery system of BBR-MgAl monolayer hydrotalcite (BBR/MLDH) was prepared to increase the solubility and b...

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Bibliographic Details
Main Authors: Aiting Wang, Wei Yang, Xinyu Yang, Xuan Mei, Tingting Hu, Ruizheng Liang, Dali Meng, Dan Yan
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Berberine
Layered double hydroxide
Monolayer nanosheets
Pharmacokinetics
Hypoglycemic effect
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303322

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