The Urosepsis—A Literature Review

• Main Authors: Mădălin Guliciuc, Adrian Cornel Maier, Ioana Maria Maier, Alin Kraft, Roxana Ramona Cucuruzac, Monica Marinescu, Cristina Şerban, Laura Rebegea, Georgiana Bianca Constantin, Dorel Firescu
• Format: Article
• Language: English
• Published: MDPI AG 2021-08-01
• Series: Medicina
• Subjects: urosepsis; review
• Online Access: https://www.mdpi.com/1648-9144/57/9/872

Urosepsis is a very serious condition with a high mortality rate. The immune response is in the center of pathophysiology. The therapeutic management of these patients includes surgical treatment of the source of infection, antibiotic therapy and life support. The management of this pathology is multidisciplinary and requires good collaboration between the urology, intensive care, imaging and laboratory medicine departments. An imbalance of pro and anti-inflammatory cytokines produced during sepsis plays an important role in pathogenesis. The study of cytokines in sepsis has important implications for understanding pathophysiology and for development of other therapeutic solutions. If not treated adequately, urosepsis may lead to serious septic complications and organ sequelae, even to a lethal outcome.