STIM1 regulates platelet-derived growth factor-induced migration and Ca2+ influx in human airway smooth muscle cells.

STIM1 regulates platelet-derived growth factor-induced migration and Ca2+ influx in human airway smooth muscle cells.

It is suggested that migration of airway smooth muscle (ASM) cells plays an important role in the pathogenesis of airway remodeling in asthma. Increases in intracellular Ca(2+) concentrations ([Ca(2+)](i)) regulate most ASM cell functions related to asthma, such as contraction and proliferation. Rec...

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Bibliographic Details
Main Authors: Nobukazu Suganuma, Satoru Ito, Hiromichi Aso, Masashi Kondo, Mitsuo Sato, Masahiro Sokabe, Yoshinori Hasegawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3439366?pdf=render

Internet

http://europepmc.org/articles/PMC3439366?pdf=render

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