Methotrexate combined with methylprednisolone for the recovery of motor function and differential gene expression in rats with spinal cord injury

Methotrexate combined with methylprednisolone for the recovery of motor function and differential gene expression in rats with spinal cord injury

Methylprednisolone is a commonly used drug for the treatment of spinal cord injury, but high doses of methylprednisolone can increase the incidence of infectious diseases. Methotrexate has anti-inflammatory activity and immunosuppressive effects, and can reduce inflammation after spinal cord injury....

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Bibliographic Details
Main Authors: Jian-tao Liu, Si Zhang, Bing Gu, Hua-nan Li, Shuo-yu Wang, Shui-yin Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; spinal cord injury; methotrexate; methylprednisolone; gait; gene expression profile; inflammation; oxidative stress; apoptosis; nerve repair; Solexa gene sequencing; secondary lesion; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=9;spage=1507;epage=1518;aulast=Liu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=9;spage=1507;epage=1518;aulast=Liu

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