Characterization of a Carbonyl Reductase from <i>Rhodococcus erythropolis</i> WZ010 and Its Variant Y54F for Asymmetric Synthesis of (<i>S</i>)-<i>N</i>-Boc-3-Hydroxypiperidine

Characterization of a Carbonyl Reductase from <i>Rhodococcus erythropolis</i> WZ010 and Its Variant Y54F for Asymmetric Synthesis of (<i>S</i>)-<i>N</i>-Boc-3-Hydroxypiperidine

The recombinant carbonyl reductase from <i>Rhodococcus erythropolis</i> WZ010 (ReCR) demonstrated strict (<i>S</i>)-stereoselectivity and catalyzed the irreversible reduction of <i>N</i>-Boc-3-piperidone (NBPO) to (<i>S</i>)-<i>N</i>-Boc-3-...

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Bibliographic Details
Main Authors: Xiangxian Ying, Jie Zhang, Can Wang, Meijuan Huang, Yuting Ji, Feng Cheng, Meilan Yu, Zhao Wang, Meirong Ying
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
(<i>S</i>)-<i>N</i>-Boc-3-hydroxypiperidine
carbonyl reductase
asymmetric reduction
rational design
<i>Rhodococcus erythropolis</i>
Online Access:https://www.mdpi.com/1420-3049/23/12/3117

Internet

https://www.mdpi.com/1420-3049/23/12/3117

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