Dual Regulation of Fbw7 Function and Oncogenic Transformation by Usp28

Dual Regulation of Fbw7 Function and Oncogenic Transformation by Usp28

Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates the turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-dependent substrate ubiquitination is antagonized by the Usp28 deubiquitinase. Here, we show that Usp28 preferentially antagonizes autoca...

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Bibliographic Details
Main Authors: Christina Schülein-Völk, Elmar Wolf, Jing Zhu, Wenshan Xu, Lyudmyla Taranets, Andreas Hellmann, Laura A. Jänicke, Markus E. Diefenbacher, Axel Behrens, Martin Eilers, Nikita Popov
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714008407

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http://www.sciencedirect.com/science/article/pii/S2211124714008407

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