Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin

It is a widely held belief that the sole effect of muscle on bone is through mechanical loading. However, as the two tissues are intimately associated, we hypothesized that muscle myokines may have positive effects on bone. We found that factors produced by muscle will protect osteocytes from underg...

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Bibliographic Details
Main Authors: K Jähn, N Lara-Castillo, L Brotto, CL Mo, ML Johnson, M Brotto, LF Bonewald
Format: Article
Language:English
Published: AO Research Institute Davos 2012-09-01
Series:European Cells & Materials
Subjects:
Online Access:http://www.ecmjournal.org/journal/papers/vol024/pdf/v024a14.pdf