Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis

Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis

Objective. To investigate whether advanced glycation endproducts (AGEs) in the skin are increased in patients with systemic sclerosis (SSc) and are related to the presence of disease-related and traditional cardiovascular risk factors. Methods. Skin autofluorescence, as a measure for the accumulatio...

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Main Authors: M. E. Hettema, H. Bootsma, R. Graaff, R. de Vries, C. G. M. Kallenberg, A. J. Smit
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Rheumatology
Online Access:http://dx.doi.org/10.1155/2011/417813
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spelling doaj-67b47ff25446449d923a3c61b2594e472020-11-24T23:15:29ZengHindawi LimitedInternational Journal of Rheumatology1687-92601687-92792011-01-01201110.1155/2011/417813417813Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic SclerosisM. E. Hettema0H. Bootsma1R. Graaff2R. de Vries3C. G. M. Kallenberg4A. J. Smit5Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDivision of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Biomedical Engineering, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDivision of Endocrinology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDivision of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDivision of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsObjective. To investigate whether advanced glycation endproducts (AGEs) in the skin are increased in patients with systemic sclerosis (SSc) and are related to the presence of disease-related and traditional cardiovascular risk factors. Methods. Skin autofluorescence, as a measure for the accumulation of AGEs, was assessed by measuring UV-A light excitation-emission matrices (AF-EEMS) in 41 SSc patients and 41 age- and sex-matched controls. Traditional cardiovascular risk factors and disease-related risk factors were recorded. Results. Skin AF-EEMS did not differ between SSc patients and controls (1.68±0.58 a.u. versus 1.63±0.41 a.u., P=0.684). Skin AF-EEMS in SSc patients was associated with levels of CRP (r=0.44, P=0.004), Medsger's severity scale (r=0.45, P=0.006), and use of agents intervening in the renin-angiotensin system (r=0.33, P=0.027). When analysing SSc patients and controls together, in multivariate analysis, only age and use of agents intervening in the renin-angiotensin system were independently associated with AF-EEMS. Conclusion. These data demonstrate that skin AGEs are not increased in SSc patients.http://dx.doi.org/10.1155/2011/417813
collection DOAJ
language English
format Article
sources DOAJ
author M. E. Hettema
H. Bootsma
R. Graaff
R. de Vries
C. G. M. Kallenberg
A. J. Smit
spellingShingle M. E. Hettema
H. Bootsma
R. Graaff
R. de Vries
C. G. M. Kallenberg
A. J. Smit
Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
International Journal of Rheumatology
author_facet M. E. Hettema
H. Bootsma
R. Graaff
R. de Vries
C. G. M. Kallenberg
A. J. Smit
author_sort M. E. Hettema
title Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
title_short Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
title_full Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
title_fullStr Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
title_full_unstemmed Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
title_sort skin autofluorescence, as marker of accumulation of advanced glycation endproducts and of cumulative metabolic stress, is not increased in patients with systemic sclerosis
publisher Hindawi Limited
series International Journal of Rheumatology
issn 1687-9260
1687-9279
publishDate 2011-01-01
description Objective. To investigate whether advanced glycation endproducts (AGEs) in the skin are increased in patients with systemic sclerosis (SSc) and are related to the presence of disease-related and traditional cardiovascular risk factors. Methods. Skin autofluorescence, as a measure for the accumulation of AGEs, was assessed by measuring UV-A light excitation-emission matrices (AF-EEMS) in 41 SSc patients and 41 age- and sex-matched controls. Traditional cardiovascular risk factors and disease-related risk factors were recorded. Results. Skin AF-EEMS did not differ between SSc patients and controls (1.68±0.58 a.u. versus 1.63±0.41 a.u., P=0.684). Skin AF-EEMS in SSc patients was associated with levels of CRP (r=0.44, P=0.004), Medsger's severity scale (r=0.45, P=0.006), and use of agents intervening in the renin-angiotensin system (r=0.33, P=0.027). When analysing SSc patients and controls together, in multivariate analysis, only age and use of agents intervening in the renin-angiotensin system were independently associated with AF-EEMS. Conclusion. These data demonstrate that skin AGEs are not increased in SSc patients.
url http://dx.doi.org/10.1155/2011/417813
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