Secretory clusterin promotes hepatocellular carcinoma progression by facilitating cancer stem cell properties via AKT/GSK-3β/β-catenin axis

Secretory clusterin promotes hepatocellular carcinoma progression by facilitating cancer stem cell properties via AKT/GSK-3β/β-catenin axis

Abstract Background To explore the modulatory effects and mechanism of secretory clusterin (sCLU) on cancer stem cell (CSC) properties in hepatocellular carcinoma (HCC). Methods The effects of sCLU repression or overexpression on chemoresistance, migration, invasion, and tumor growth were detected b...

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Bibliographic Details
Main Authors: Wenjie Zheng, Min Yao, Mengna Wu, Junling Yang, Dengfu Yao, Li Wang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
Secretory clusterin
β-Catenin
Cancer stem cell
Molecular target
Online Access:https://doi.org/10.1186/s12967-020-02262-7

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