Normal T cell selection occurs in CD205-deficient thymic microenvironments.

Normal T cell selection occurs in CD205-deficient thymic microenvironments.

The thymus imparts a developmental imprint upon T cells, screening beneficial and self-tolerant T cell receptor (TCR) specificities. Cortical thymic epithelial cells (CTEC) present self-peptide self-MHC complexes to thymocytes, positively selecting those with functional TCRs. Importantly, CTEC gener...

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Bibliographic Details
Main Authors: William E Jenkinson, Kyoko Nakamura, Andrea J White, Eric J Jenkinson, Graham Anderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3534071?pdf=render

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