Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature

Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature

Blue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation (VM) that may affect any tissue or organ but mainly affects the skin, subcutaneous tissue and gastrointestinal (GI) tract. Patients present with serious anemia, treated with lifelong iron supplements and frequent blood...

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Bibliographic Details
Main Authors: Bayan Musaed AlNooh, Nada Ghazi AlQadri, Muhtadi Alghubayn, Saad Mohammed AlAjlan
Format: Article
Language:English
Published: Karger Publishers 2021-07-01
Series:Case Reports in Dermatology
Subjects:
blue rubber bleb nevus syndrome
brbns
sirolimus
vascular malformation
Online Access:https://www.karger.com/Article/FullText/511535
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spelling doaj-67ade58dbd7f4b6ba33f114d81e5f20f2021-08-26T15:05:18ZengKarger PublishersCase Reports in Dermatology1662-65672021-07-0113241742110.1159/000511535511535Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the LiteratureBayan Musaed AlNooh0Nada Ghazi AlQadri1Muhtadi Alghubayn2Saad Mohammed AlAjlan3Department of Dermatology, King Saud University and King Khalid University Hospital, Riyadh, Saudi ArabiaDepartment of Dermatology, King Saud Medical City, Riyadh, Saudi ArabiaDepartment of Medicine, King Saud Medical City, Riyadh, Saudi ArabiaDepartment of Dermatology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi ArabiaBlue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation (VM) that may affect any tissue or organ but mainly affects the skin, subcutaneous tissue and gastrointestinal (GI) tract. Patients present with serious anemia, treated with lifelong iron supplements and frequent blood transfusion secondary to chronic GI bleeding. Variable therapeutic modalities were used in the management of BRBNS; sirolimus (SRL), a mammalian target of rapamycin (mTOR) inhibitor, is found to be a promising therapy for vascular anomalies.https://www.karger.com/Article/FullText/511535blue rubber bleb nevus syndromebrbnssirolimusvascular malformation
collection DOAJ
language English
format Article
sources DOAJ
author Bayan Musaed AlNooh
Nada Ghazi AlQadri
Muhtadi Alghubayn
Saad Mohammed AlAjlan
spellingShingle Bayan Musaed AlNooh
Nada Ghazi AlQadri
Muhtadi Alghubayn
Saad Mohammed AlAjlan
Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature
Case Reports in Dermatology
blue rubber bleb nevus syndrome
brbns
sirolimus
vascular malformation
author_facet Bayan Musaed AlNooh
Nada Ghazi AlQadri
Muhtadi Alghubayn
Saad Mohammed AlAjlan
author_sort Bayan Musaed AlNooh
title Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature
title_short Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature
title_full Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature
title_fullStr Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature
title_full_unstemmed Sirolimus in the Management of Blue Rubber Bleb Nevus Syndrome: A Case Report and Review of the Literature
title_sort sirolimus in the management of blue rubber bleb nevus syndrome: a case report and review of the literature
publisher Karger Publishers
series Case Reports in Dermatology
issn 1662-6567
publishDate 2021-07-01
description Blue rubber bleb nevus syndrome (BRBNS) is a rare multifocal venous malformation (VM) that may affect any tissue or organ but mainly affects the skin, subcutaneous tissue and gastrointestinal (GI) tract. Patients present with serious anemia, treated with lifelong iron supplements and frequent blood transfusion secondary to chronic GI bleeding. Variable therapeutic modalities were used in the management of BRBNS; sirolimus (SRL), a mammalian target of rapamycin (mTOR) inhibitor, is found to be a promising therapy for vascular anomalies.
topic blue rubber bleb nevus syndrome
brbns
sirolimus
vascular malformation
url https://www.karger.com/Article/FullText/511535
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AT nadaghazialqadri sirolimusinthemanagementofbluerubberblebnevussyndromeacasereportandreviewoftheliterature
AT muhtadialghubayn sirolimusinthemanagementofbluerubberblebnevussyndromeacasereportandreviewoftheliterature
AT saadmohammedalajlan sirolimusinthemanagementofbluerubberblebnevussyndromeacasereportandreviewoftheliterature
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