Oxytocin Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord

Oxytocin Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord

Objective: Oxytocin (OT) is synthesized within the paraventricular nucleus and supraoptic nucleus of the hypothalamus. In addition to its role in uterine contraction, OT plays an important antinociceptive role; however, the underlying molecular mechanisms of antinociceptive role of OT remain elusive...

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Bibliographic Details
Main Authors: Wuping Sun, Qian Zhou, Xiyuan Ba, Xiaojin Feng, Xuexue Hu, Xiaoe Cheng, Tao Liu, Jing Guo, Lizu Xiao, Jin Jiang, Donglin Xiong, Yue Hao, Zixian Chen, Changyu Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
oxytocin
neuropathic pain
TRPV1
GABA
spinal cord
mechanical allodynia
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00248/full

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