Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer

Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer

Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tiss...

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Main Authors: Xiaodong Feng, Zhijun Zhang, Peng Sun, Guanghui Song, Lu Wang, Zhenqing Sun, Ning Yuan, Qing Wang, Limin Lun
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2020/6439614
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spelling doaj-679bea2e00b04d72b0554ef1d51f02c22020-12-07T09:08:23ZengHindawi LimitedDisease Markers0278-02401875-86302020-01-01202010.1155/2020/64396146439614Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon CancerXiaodong Feng0Zhijun Zhang1Peng Sun2Guanghui Song3Lu Wang4Zhenqing Sun5Ning Yuan6Qing Wang7Limin Lun8Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, ChinaDepartment of Clinical Laboratory, Taian City Central Hospital, Taian 271000, ChinaDepartment of Pathology, Taian City Central Hospital, Taian 271000, ChinaDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, ChinaDepartment of Education and Training, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, ChinaDepartment of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, ChinaDepartment of Clinical Laboratory, The Seventh Medical Center of PLA General Hospital, Bejing 100010, ChinaDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, ChinaDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, ChinaInterleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size (P=0.001) and American Joint Committee on Cancer (AJCC) stage (P=0.013). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients.http://dx.doi.org/10.1155/2020/6439614
collection DOAJ
language English
format Article
sources DOAJ
author Xiaodong Feng
Zhijun Zhang
Peng Sun
Guanghui Song
Lu Wang
Zhenqing Sun
Ning Yuan
Qing Wang
Limin Lun
spellingShingle Xiaodong Feng
Zhijun Zhang
Peng Sun
Guanghui Song
Lu Wang
Zhenqing Sun
Ning Yuan
Qing Wang
Limin Lun
Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
Disease Markers
author_facet Xiaodong Feng
Zhijun Zhang
Peng Sun
Guanghui Song
Lu Wang
Zhenqing Sun
Ning Yuan
Qing Wang
Limin Lun
author_sort Xiaodong Feng
title Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_short Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_full Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_fullStr Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_full_unstemmed Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer
title_sort interleukin-18 is a prognostic marker and plays a tumor suppressive role in colon cancer
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2020-01-01
description Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size (P=0.001) and American Joint Committee on Cancer (AJCC) stage (P=0.013). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients.
url http://dx.doi.org/10.1155/2020/6439614
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AT zhijunzhang interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
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AT liminlun interleukin18isaprognosticmarkerandplaysatumorsuppressiveroleincoloncancer
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