Molecular Characterization of Lys49 and Asp49 Phospholipases A2 from Snake Venom and Their Antiviral Activities against Dengue virus

Molecular Characterization of Lys49 and Asp49 Phospholipases A2 from Snake Venom and Their Antiviral Activities against Dengue virus

We report the detailed molecular characterization of two PLA2s, Lys49 and Asp49 isolated from Bothrops leucurus venom, and examined their effects against Dengue virus (DENV). The Bl-PLA2s, named BlK-PLA2 and BlD-PLA2, are composed of 121 and 122 amino acids determined by automated sequencing of the...

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Bibliographic Details
Main Authors: Andre L. Fuly, Johannes A. Eble, Eladio F. Sanchez, Maria I. Estevão-Costa, Valeria G. Alvarenga, Francisco S. Schneider, Gustavo B. Naumann, Michael Richardson, Raiana A. De Oliveira, Arthur S. B. Santos, Sergio Caldas, Alzira B. Cecilio
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Toxins
Subjects:
svPLA2s
Bothrops leucurus
Dengue virus
antiviral effect
Real-Time PCR
Online Access:http://www.mdpi.com/2072-6651/5/10/1780

Internet

http://www.mdpi.com/2072-6651/5/10/1780

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