High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

Abstract Metabolic changes induced by high fat diet (HFD) that contribute to osteoarthritis (OA) are poorly understood. We investigated longitudinal changes to metabolites and their contribution to OA pathogenesis in response to HFD. HFD-fed mice exhibited acceleration of spontaneous age-related and...

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Main Authors: Poulami Datta, Yue Zhang, Alexa Parousis, Anirudh Sharma, Evgeny Rossomacha, Helal Endisha, Brian Wu, Izabela Kacprzak, Nizar N. Mahomed, Rajiv Gandhi, Jason S. Rockel, Mohit Kapoor
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07963-6

Internet

https://doi.org/10.1038/s41598-017-07963-6

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