A clinical case of hereditary thrombophilia in a patient with ulcerative colitis

• Main Authors: N. A. Fadeeva, I. A. Donchenko, O. V. Knyazev, A. A. Lishchinskaya, G. A. Dudina, I. N. Ruchkina, V. V. Subbotin, K. K. Noskova, V. A. Rogozina, A. I. Parfenov
• Format: Article
• Language: Russian
• Published: MONIKI 2017-12-01
• Series: Alʹmanah Kliničeskoj Mediciny
• Subjects: ulcerative colitis; coagulopathy; thrombophilia; thromboembolic complications
• Online Access: https://www.almclinmed.ru/jour/article/view/619

We present  a clinical case of a 24-year old female patient  who was hospitalized  with high active ulcerative  colitis associated  with  latent  hereditary thrombophilia  uncontrolled  due  to  the  exacerbation  of ulcerative colitis and local steroid treatment. The patient  was treated with combination of systemic steroids, adalimumab and anticoagulants. We emphasize  the necessity of the multidisciplinary approach  to her treatment. The clinical case demonstrates the possibility of safe use of anticoagulants to prevent  thromboembolic complications in patients  with ulcerative colitis and high risk of thrombus formation, under careful monitoring of coagulation  parameters and thromboelastography. We discuss the need  in clear guidelines to determine treatment strategy for patients  with inflammatory bowel diseases, coagulopathies and thromboembolic complications.