Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital

Abstract Background The accuracy, safety and feasibility of, the compounding robot APOTECAchemo were evaluated in the clinical practice of Japan. Methods Accuracy and precision of robotic preparations by APOTECAchemo was evaluated in 20 preparations of fluorouracil (FU) and cyclophosphamide (CPA) in...

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Main Authors: Takuya Iwamoto, Takuya Morikawa, Miki Hioki, Hirofumi Sudo, Demis Paolucci, Masahiro Okuda
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40780-017-0081-z
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spelling doaj-677fdbce0eda4ffda5c3dbb8e86cfd9a2020-11-24T21:59:47ZengBMCJournal of Pharmaceutical Health Care and Sciences2055-02942017-04-01311810.1186/s40780-017-0081-zPerformance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospitalTakuya Iwamoto0Takuya Morikawa1Miki Hioki2Hirofumi Sudo3Demis Paolucci4Masahiro Okuda5Department of Pharmacy, Mie University HospitalDepartment of Pharmacy, Mie University HospitalDepartment of Pharmacy, Mie University HospitalDepartment of Pharmacy, Mie University HospitalLoccioni Humancare, Moie di MaiolatiDepartment of Pharmacy, Mie University HospitalAbstract Background The accuracy, safety and feasibility of, the compounding robot APOTECAchemo were evaluated in the clinical practice of Japan. Methods Accuracy and precision of robotic preparations by APOTECAchemo was evaluated in 20 preparations of fluorouracil (FU) and cyclophosphamide (CPA) infusions by four pharmacists. Environmental and product contaminations with FU and CPA were evaluated by wipe testing. Robotic performance was compared with manual preparation in a biological safety cabinet. The number of robotic products, total compounding time and total pre-reconstitution time of lyophilized drugs between January 1, 2014 to December 31, 2015 were investigated. Results Robotic preparation resulted more accurate and precise (mean absolute dose error and coefficient of variation were 0.83 and 1.04% for FU and 0.52 and 0.59% for CPA) than those of manual preparation (respective values were 1.20 and 1.46% for FU and 1.70 and 2.20% for CPA). Drug residue was not detected from any of the prepared infusion bags with the robotic preparation, whereas FU was detected in two of four analyzed infusion bags with manual preparation. Average total time to make single anticancer drug preparation (compounding plus reconstitution of lyophilized drugs) was 6.11 min in the second half of 2015. During the study period, the highest percentage of production covered by APOTECAchemo was 70.4% of the total inpatient pharmacy activity. Conclusion Robotic preparation using APOTECAchemo should give substantial advantages in drug compounding for accuracy and safety and was able to be successfully worked in Mie university hospital.http://link.springer.com/article/10.1186/s40780-017-0081-zRobotic preparationChemotherapyWipe testAPOTECAchemoJapanese hospitalPharmacy automation
collection DOAJ
language English
format Article
sources DOAJ
author Takuya Iwamoto
Takuya Morikawa
Miki Hioki
Hirofumi Sudo
Demis Paolucci
Masahiro Okuda
spellingShingle Takuya Iwamoto
Takuya Morikawa
Miki Hioki
Hirofumi Sudo
Demis Paolucci
Masahiro Okuda
Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital
Journal of Pharmaceutical Health Care and Sciences
Robotic preparation
Chemotherapy
Wipe test
APOTECAchemo
Japanese hospital
Pharmacy automation
author_facet Takuya Iwamoto
Takuya Morikawa
Miki Hioki
Hirofumi Sudo
Demis Paolucci
Masahiro Okuda
author_sort Takuya Iwamoto
title Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital
title_short Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital
title_full Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital
title_fullStr Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital
title_full_unstemmed Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital
title_sort performance evaluation of the compounding robot, apotecachemo, for injectable anticancer drugs in a japanese hospital
publisher BMC
series Journal of Pharmaceutical Health Care and Sciences
issn 2055-0294
publishDate 2017-04-01
description Abstract Background The accuracy, safety and feasibility of, the compounding robot APOTECAchemo were evaluated in the clinical practice of Japan. Methods Accuracy and precision of robotic preparations by APOTECAchemo was evaluated in 20 preparations of fluorouracil (FU) and cyclophosphamide (CPA) infusions by four pharmacists. Environmental and product contaminations with FU and CPA were evaluated by wipe testing. Robotic performance was compared with manual preparation in a biological safety cabinet. The number of robotic products, total compounding time and total pre-reconstitution time of lyophilized drugs between January 1, 2014 to December 31, 2015 were investigated. Results Robotic preparation resulted more accurate and precise (mean absolute dose error and coefficient of variation were 0.83 and 1.04% for FU and 0.52 and 0.59% for CPA) than those of manual preparation (respective values were 1.20 and 1.46% for FU and 1.70 and 2.20% for CPA). Drug residue was not detected from any of the prepared infusion bags with the robotic preparation, whereas FU was detected in two of four analyzed infusion bags with manual preparation. Average total time to make single anticancer drug preparation (compounding plus reconstitution of lyophilized drugs) was 6.11 min in the second half of 2015. During the study period, the highest percentage of production covered by APOTECAchemo was 70.4% of the total inpatient pharmacy activity. Conclusion Robotic preparation using APOTECAchemo should give substantial advantages in drug compounding for accuracy and safety and was able to be successfully worked in Mie university hospital.
topic Robotic preparation
Chemotherapy
Wipe test
APOTECAchemo
Japanese hospital
Pharmacy automation
url http://link.springer.com/article/10.1186/s40780-017-0081-z
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