Genome-Wide Analysis of Known and Potential Tetraspanins in <i>Entamoeba histolytica</i>

• Main Authors: Kentaro Tomii, Herbert J. Santos, Tomoyoshi Nozaki
• Format: Article
• Language: English
• Published: MDPI AG 2019-11-01
• Series: Genes
• Subjects: tetraspanin; entamoeba; membrane protein; subcellular localization; intron
• Online Access: https://www.mdpi.com/2073-4425/10/11/885

Tetraspanins are membrane proteins involved in intra- and/or intercellular signaling, and membrane protein complex formation. In some organisms, their role is associated with virulence and pathogenesis. Here, we investigate known and potential tetraspanins in the human intestinal protozoan parasite <i>Entamoeba histolytica</i>. We conducted sequence similarity searches against the proteome data of <i>E. histolytica</i> and newly identified nine uncharacterized proteins as potential tetraspanins in <i>E. histolytica</i>. We found three subgroups within known and potential tetraspanins, as well as subgroup-associated features in both their amino acid and nucleotide sequences. We also examined the subcellular localization of a few representative tetraspanins that might be potentially related to pathogenicity. The results in this study could be useful resources for further understanding and downstream analyses of tetraspanins in <i>Entamoeba</i>.