Substrate recognition and function of the R2TP complex in response to cellular stress

Substrate recognition and function of the R2TP complex in response to cellular stress

The R2TP complex is a HSP90 co-chaperone, which consists of four subunits: PIH1D1, RPAP3, RUVBL1 and RUVBL2. It is involved in the assembly of large protein or protein-RNA complexes such as RNA polymerase, small nucleolar ribonucleoproteins (snoRNPs), phosphatidylinositol 3 kinase-related kinases (P...

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Bibliographic Details
Main Authors: Patrick evon Morgen, Zuzana eHorejsi, Libor eMacurek
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Genetics
Subjects:
Protein Folding
Cancer
cellular stress
DNA damage response
R2TP complex
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00069/full

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