Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach

Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach

The application of physiologically based pharmacokinetic models to nanoparticles is still very restricted and challenging, owing to the complicated in vivo transport mechanisms involving nanoparticles, including phagocytosis, enhanced permeability and retention effects, cellular recognition, and int...

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Bibliographic Details
Main Authors:	Lei Li, Haisheng He, Sifang Jiang, Jianping Qi, Yi Lu, Ning Ding, Hai-Shu Lin, Wei Wu, Xiaoqiang Xiang
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Molecules
Subjects:	physiologically based pharmacokinetic model methoxy poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles phagocytosis biodistribution
Online Access:	https://www.mdpi.com/1420-3049/26/5/1271

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