Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.

Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.

The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while enduring high amyloid plaque loads for decades...

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Bibliographic Details
Main Authors: Chera L Maarouf, Ian D Daugs, Tyler A Kokjohn, Douglas G Walker, Jesse M Hunter, Jane C Kruchowsky, Randy Woltjer, Jeffrey Kaye, Eduardo M Castaño, Marwan N Sabbagh, Thomas G Beach, Alex E Roher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3210154?pdf=render

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http://europepmc.org/articles/PMC3210154?pdf=render

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