Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.

Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.

The aggressiveness of pancreatic ductal adenocarcinoma (PDA) is characterized by its high metastatic potential and lack of effective therapies, which is the result of a lack of understanding of the mechanisms involved in promoting PDA metastases. We identified Annexin A2 (ANXA2), a member of the Ann...

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Main Authors: Lei Zheng, Kelly Foley, Lanqing Huang, Ashley Leubner, Guanglan Mo, Kelly Olino, Barish H Edil, Masamichi Mizuma, Rajni Sharma, Dung T Le, Robert A Anders, Peter B Illei, Jennifer E Van Eyk, Anirban Maitra, Daniel Laheru, Elizabeth M Jaffee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084841?pdf=render

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