Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division.

Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division.

Paternal exposures to cancer chemotherapeutics or environmental chemicals may have adverse effects on progeny outcome that are manifested in the preimplantation embryo. The objectives of this study were to determine the impact of paternal exposure to cyclophosphamide, an anticancer alkylating agent,...

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Bibliographic Details
Main Authors: Lisanne Grenier, Bernard Robaire, Barbara F Hales
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3217984?pdf=render

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