Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome

Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome

Abstract There is an unmet need and urgency to find safe and effective anti-obesity interventions. Our recent study in mice fed on obesogenic diet found that treatment with the alcohol aversive drug disulfiram reduced feeding efficiency and led to a decrease in body weight and an increase in energy...

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Main Authors: Michel Bernier, Dylan Harney, Yen Chin Koay, Antonio Diaz, Abhishek Singh, Devin Wahl, Tamara Pulpitel, Ahmed Ali, Vince Guiterrez, Sarah J. Mitchell, Eun-Young Kim, John Mach, Nathan L. Price, Miguel A. Aon, David G. LeCouteur, Victoria C. Cogger, Carlos Fernandez-Hernando, John O’Sullivan, Mark Larance, Ana Maria Cuervo, Rafael de Cabo
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-020-0046-6

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