Efficacy and Initial Safety Profile of CXCL12 Treatment in a Rodent Model of Urinary Sphincter Deficiency

Abstract Disappointing results of skeletal muscle precursor cell (skMPC) therapy for women with intrinsic urinary sphincter deficiency (ISD) associated urinary incontinence has increased interest in alternative sphincter regenerative approaches. This study was to measure the safety and efficacy of t...

Full description

Bibliographic Details
Main Authors:	J. Koudy Williams, Ashley Dean, Shannon Lankford, Karl‐Erik Andersson
Format:	Article
Language:	English
Published:	Wiley 2017-08-01
Series:	Stem Cells Translational Medicine
Subjects:	Intrinsic urinary sphincter deficiency Skeletal muscle precursor cells Stress urinary incontinence Stromal derived factor‐1α CXCL12
Online Access:	https://doi.org/10.1002/sctm.16-0497

Similar Items

The impact of incontinence etiology on artificial urinary sphincter outcomes
by: Adam R. Miller, et al.
Published: (2017-07-01)

Artificial Urinary Sphincter for Postradical Prostatectomy Urinary Incontinence — Is It the Best Option?
by: Yun-Sok Ha, et al.
Published: (2019-12-01)

Artificial urinary sphincter revision for urethral atrophy: comparing single cuff downsizing and tandem cuff placement
by: Brian J. Linder, et al.

The experience of artificial urinary sphincter implantation by a single surgeon in 15 years
by: Yuan-Chi Shen, et al.
Published: (2013-03-01)

Artificial urinary sphincter: current status and future directions
by: Culley C Carson
Published: (2020-01-01)

Artificial urinary sphincters for treating postprostatectomy incontinence: A contemporary experience from the UK
by: Serag H, et al.
Published: (2018-09-01)

Urethral Catheterization in Men With Artificial Urinary Sphincter: Clinical and Legal Implications
by: Rafael Boscolo-Berto, et al.
Published: (2012-08-01)

What is the fate of artificial urinary sphincters among men undergoing repetitive bladder cancer treatment?
by: S. Mitchell Heiner, et al.
Published: (2018-01-01)

Targeting Moderate and Severe Male Stress Urinary Incontinence With Adjustable Male Slings and the Perineal Artificial Urinary Sphincter: Focus on Perioperative Complications and Device Explantations
by: Alexander Kretschmer, et al.
Published: (2017-06-01)

Artificial urinary sphincters for male stress urinary incontinence: current perspectives
by: Cordon BH, et al.
Published: (2016-07-01)

Artificial urinary sphincter implantation: an important component of complex surgery for urinary tract reconstruction in patients with refractory urinary incontinence
by: Fan Zhang, et al.
Published: (2018-01-01)

Artificial urinary sphincter for urinary incontinence after radical prostatectomy: a historical cohort from 2004 to 2015
by: Augusto Cesar Soares dos Santos Junior, et al.

The artificial urinary sphincter and male sling for postprostatectomy incontinence: Which patient should get which procedure?
by: Craig V. Comiter, et al.
Published: (2016-01-01)

Proof of concept: Exposing the myth of urethral atrophy after artificial urinary sphincter via assessment of circumferential recovery after capsulotomy and intraoperative pressure profiling of the pressure regulating balloon
by: Amy Marcia Pearlman, et al.
Published: (2018-07-01)

Artificial sphincter “BR - SL - AS 904” in the treatment of urinary incontinence after radical prostatectomy: efficacy, practicality and safety in a prospective and multicenter study
by: Salvador Vilar Correia Lima, et al.

The impact of perioperative complications on favorable outcomes after artificial urinary sphincter implantation for post-prostatectomy incontinence
by: Alexander Kretschmer, et al.

Single perineal incision placement of artificial urinary sphincter with cadaveric correlation of sub-dartos pump placement
by: Cooper R. Benson, et al.

Long-term (>5 years) outcomes of patients implanted with artificial urinary sphincter: A single-center experience
by: Alejandro Abello, et al.
Published: (2019-01-01)

The first experience in Africa: urinary artificial sphincter type ZSI 375 PF for treatment of stress urinary incontinence in men
by: Ali Barki, et al.
Published: (2020-02-01)

A comparison of artificial urinary sphincter outcomes after primary implantation and first revision surgery
by: Kevin J. Hebert, et al.
Published: (2021-07-01)

Long-term results of the implantation of the AMS 800 artificial sphincter for post-prostatectomy incontinence: a single-center experience
by: Carlos Alberto Ricetto Sacomani, et al.

Salvage surgical procedure for artificial sphincter extrusion
by: Flavio Trigo Rocha, et al.

Outcomes following mid-urethral sling placement in patients with intrinsic sphincteric deficiency: comparison of Sparc and Monarc slings
by: David E. Rapp, et al.
Published: (2009-02-01)

Long-term efficacy and safety of artificial urinary sphincter AMS 800<sup>ТМ</sup> implantations
by: E. I. Veliev, et al.
Published: (2021-03-01)

Cell Versus Chemokine Therapy Effects on Cell Mobilization to Chronically Dysfunctional Urinary Sphincters of Nonhuman Primates
by: J. Koudy Williams, et al.
Published: (2018-12-01)

Single piece artificial urinary sphincter for secondary incontinence following successful repair of post traumatic urethral injury
by: D K Kandpal, et al.
Published: (2013-01-01)

Clinical Factors Associated with Low Valsalva Leak Point Pressure Among Women with Stress Urinary Incontinence
by: Sun-Ouck Kim, et al.
Published: (2011-12-01)

Ultrasound evaluation of the striated urethral sphincter as a predictive parameter of urinary continence after radical prostatectomy
by: Lucio Dell’Atti
Published: (2016-01-01)

Radiotherapy is associated with reduced continence outcomes following implantation of the artificial urinary sphincter in men with post-radical prostatectomy incontinence
by: Stephanie Guillaumier, et al.
Published: (2017-01-01)

Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): study protocol for a randomised controlled trial
by: Lynda Constable, et al.
Published: (2018-02-01)

Clinical and urodynamic evaluation in women with stress urinary incontinence treated by periurethral collagen injection
by: S.B. Martins, et al.
Published: (2007-10-01)

Artificial urinary sphincter surgery in the special populations: neurological, revision, concurrent penile prosthesis and female stress urinary incontinence groups
by: Eric Chung
Published: (2020-01-01)

World record: Single AMS 800 artificial urinary sphincter functioning uninterrupted for 29 years in male paraplegic patient
by: Peter Rehder, et al.
Published: (2020-09-01)

A Combined Technology to Protect the Anatomic Integrity of Distal Urethral Sphincter Complex in Radical Prostatectomy Improves Early Urinary Continence Recovery Without Sacrifice of Oncological Outcomes
by: Ao Liu, et al.
Published: (2021-08-01)

Adjustment of tension applied in transobturator tapes in females with intrinsic sphincteric deficiency: Two centers' prospective, comparative, randomized surgical trial
by: Wally Mahfouz, et al.
Published: (2021-01-01)

Injectable Bulking Agents for Urinary Incontinence after Radical Prostatectomy, Mimicking Local Recurrence: A Case Report
by: Jehong Yoon, et al.
Published: (2017-02-01)

Synthetic pubovaginal sling (TVT): failure in conservative treatment following vaginal exteriorization
by: Edgar Thorell, et al.
Published: (2004-04-01)

Longitudinal urethral sling with prepubic and retropubic fixation for male urinary incontinence
by: Carlos H. Schaal, et al.
Published: (2004-08-01)

Clinical and Functional Anatomy of the Urethral Sphincter
by: Junyang Jung, et al.
Published: (2012-09-01)

Development of a rabbit's urethral sphincter deficiency animal model for anatomical-functional evaluation
by: M. Skaff, et al.
Published: (2012-02-01)