Three New and Eleven Known Unusual C25 Steroids: Activated Production of Silent Metabolites in a Marine-Derived Fungus by Chemical Mutagenesis Strategy using Diethyl Sulphate

Three New and Eleven Known Unusual C25 Steroids: Activated Production of Silent Metabolites in a Marine-Derived Fungus by Chemical Mutagenesis Strategy using Diethyl Sulphate

Three new (1–3) and 11 known (4–14) C25 steroids with an unusual bicyclo[4.4.1]A/B ring system were isolated by tracing newly produced metabolites in the EtOAc extract of an antitumor mutant AD-1-2 obtained by the diethyl sulphate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. H...

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Bibliographic Details
Main Authors: Ming-Wen Xia, Cheng-Bin Cui, Chang-Wei Li, Chang-Jing Wu
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Marine Drugs
Subjects:
C25 steroids
antineocyclocitrinol
23-O-methylantineocyclocitrinol
structure determination
Mo2-induced CD
dimolybdenum tetracetate
Penicillium purpurogenum
marine-derived fungus
DES mutagenesis
Online Access:http://www.mdpi.com/1660-3397/12/3/1545

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