Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration

Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration

ABSTRACT: Objective To explore the velocity-effect relationship in order to the establish linearization of effect on an equation with regard to the consistency of the Hill dose-effect expression with the metabolic kinetics of receptors.Methods The linear velocity-effect expression was obtained by so...

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Bibliographic Details
Main Authors: Run-Nan LIU, Yu TANG, Ping-An LIU, Wen-Long LIU, Qi-Meng FAN, Si-Yang CHEN, Peng HE, Hai-Ying LI, Fu-Yuan HE, Kai-Wen DENG
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-09-01
Series:Digital Chinese Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589377719300278

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