<b>Conversion of <i>Vernonia galamensis</i> oil to pyridinyl-vernolamides and their antimicrobial activities</b>

• Main Authors: M.N. Mbugua, A.O. Yusuf, P.M. Gitu, B.M. Bhatt
• Format: Article
• Language: English
• Published: Chemical Society of Ethiopia 2007-04-01
• Series: Bulletin of the Chemical Society of Ethiopia
• Subjects: <i>Vernonia galamensis</i>; 2-Aminopyridine; N-(2-pyridinylmethyl)vernolamide; N-(2-pyridinylethyl)vernolamide; Antimicrobial activity
• Online Access: http://www.ajol.info/index.php/bcse/article/view/61384

Vernonia oil obtained by Soxhlet extraction from the seeds of <i>Vernonia galamensis</i> ssp. <i>nairobensis</i> was reacted with 2-aminopyridine, 2-(aminomethyl)pyridine and 2-(aminoethyl)pyridine using a 1:3 mole ratio of vernonia oil to amine at varied temperatures to give the corresponding vernolamides. The expected vernolamide from the reaction of 2-aminopyridine and the oil was not formed. N-(2-pyridinylmethyl)vernolamide and N-(2-pyridinylethyl)vernolamide exhibited antibacterial activity that was shown to be higher against gram-positive (<i>Bacillus subtilis</i>) than gram-negative (<i>Escherichia coli</i>) bacteria. The vernolamides did not show any antifungal activity.