Behavioral inhibition and dual mechanisms of anxiety risk: Disentangling neural correlates of proactive and reactive control

• Main Authors: Emilio A. Valadez, Sonya V. Troller‐Renfree, George A. Buzzell, Heather A. Henderson, Andrea Chronis‐Tuscano, Daniel S. Pine, Nathan A. Fox
• Format: Article
• Language: English
• Published: Wiley 2021-07-01
• Series: JCPP Advances
• Subjects: adolescence; anxiety; behavioral inhibition; cognitive control; EEG
• Online Access: https://doi.org/10.1002/jcv2.12022

Abstract Background Behavioral inhibition (BI) is a temperament style characterized by heightened reactivity and negative affect in response to novel people and situations, and it predicts anxiety problems later in life. However, not all BI children develop anxiety problems, and mounting evidence suggests that how one manages their cognitive resources (cognitive control) influences anxiety risk. The present study tests whether more (proactive control) or less (reactive control) planful cognitive strategies moderate relations between early BI and later anxiety. Methods Participants included 112 adolescents (55% female; Mage = 15.4 years) whose temperament was assessed during toddlerhood. In adolescence, participants completed an AX Continuous Performance Test while electroencephalography was recorded to disentangle neural activity related to proactive (cue‐locked P3b) and reactive (probe‐locked N2) control. Results Greater BI was associated with greater total anxiety scores only among adolescents with smaller ΔP3bs and larger ΔN2s—a pattern consistent with decreased reliance on proactive strategies and increased reliance on reactive strategies. Additionally, a larger ΔP3b was associated with greater total anxiety scores; however, this effect was largely explained by the fact that females tended to have larger ΔP3bs and greater anxiety than males. Conclusions Early BI relates to risk for later anxiety specifically among adolescents who rely less on proactive strategies and more on reactive control strategies. Thus, cognitive control strategy moderates the association between developmental context (i.e., temperament) and later anxiety. The present study is the first to characterize how proactive and reactive control uniquely relate to pathways toward anxiety risk.